doi: 10.1016/j.tim.2004.09.008.
Bacterial gene regulation: from transcription attenuation to riboswitches and ribozymes
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- PMID: 15488385
- DOI: 10.1016/j.tim.2004.09.008
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Bacterial gene regulation: from transcription attenuation to riboswitches and ribozymes
Trends Microbiol.
2004 Nov.
Abstract
Since the discovery of transcription attenuation as a mechanism of bacterial gene regulation, a broad variety of attenuation mechanisms have been unveiled and analysed. In 2002, the first convincing experimental evidence for metabolite-mediated attenuation, termed riboswitch, was published. Subsequently, riboswitches have been found to be widespread among bacteria and are also used in some eukaryotes. A surprising new finding has been a riboswitch acting as a metabolite-responsive ribozyme - the first new naturally occurring ribozyme discovered since 1990.
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