doi: 10.1016/j.ccr.2004.09.020.
Antagonism of Myc functions by Arf
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- PMID: 15488753
- DOI: 10.1016/j.ccr.2004.09.020
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Antagonism of Myc functions by Arf
Cancer Cell.
2004 Oct.
Free article
Abstract
The Arf-Mdm2-p53 tumor suppressor pathway is activated by sustained hyperproliferative signals emanating from oncoproteins such as Myc. A recent study reveals a novel level of feedback control, whereby induced p19(Arf) binds to Myc and blocks cell proliferation by selectively impairing its transactivation functions.
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