Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2004 Nov;186(21):7025-8.
doi: 10.1128/JB.186.21.7025-7028.2004.

Bacteriophage P1 in retrospect and in prospect

Michael B Yarmolinsky  1
Affiliations
Comment

Bacteriophage P1 in retrospect and in prospect

Michael B Yarmolinsky. J Bacteriol. 2004 Nov.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
The tripartite immunity circuitry of P1. The diagram is based largely on work reviewed in reference . Additional relevant citations can be found in the accompanying report (10), which the reader is urged to consult. Gray boxes representing genes are drawn approximately to scale. The central circle represents the P1 genome. O, C1 binding sites; P, promoters. The capacity of certain gene products to bind to a target is indicated by a line from the ligand to its target (at the blunt end). Target sites, except for C1 binding sites (see the boxed key), are indicated by thick dashed vertical lines. The site to which Cre binds is a locus of site-specific recombination (lox). The binding of ArgR to a putative binding site nearby is presumed to assist in constraining the directionality of the recombination reaction towards dimer resolution. ArgR, LexA, and RNase P are bacterial proteins. The arrow from sas (site of ant specificity) to Ant1-Ant2 (the complex of the two Ant proteins) signifies that the complex is activated by binding to sas, from which site it can alleviate repression at flanking operator sites in cis. The alternative transcripts that code for C4 RNA, Icd and the Ant proteins are indicated by wiggly lines. Regions of these transcripts marked with a prime are indicated by dashed connecting lines as susceptible of interaction with similarly named, complementary regions that are unprimed. Note that a point mutation in region a2 that confers virulence (constitutive Ant synthesis) can be suppressed by a complementary mutation in region a′. The complementarity of region j with region j′ was pointed out by Jochen Heinrich (personal communication). RBS (overlapping region b2), ribosome binding site used for the expression of icd and ant1.
See this image and copyright information in PMC

Comment on

  • Genome of bacteriophage P1.
    Łobocka MB, Rose DJ, Plunkett G 3rd, Rusin M, Samojedny A, Lehnherr H, Yarmolinsky MB, Blattner FR. Łobocka MB, et al. J Bacteriol. 2004 Nov;186(21):7032-68. doi: 10.1128/JB.186.21.7032-7068.2004. J Bacteriol. 2004. PMID: 15489417 Free PMC article.

References

    1. Arber, W., and D. Dussoix. 1962. Host specificity of DNA produced by Escherichia coli. I. Host controlled modification of bacteriophage lambda. J. Mol. Biol. 5:18-36. - PubMed
    1. Arkin, A., J. Ross, and H. H. McAdams. 1998. Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected Escherichia coli cells. Genetics 149:1633-1648. - PMC - PubMed
    1. Bickle, T. A. 2004. Restricting restriction. Mol. Microbiol. 51:3-5. - PubMed
    1. Boyd, E. F., B. M. Davis, and B. Hochhut. 2001. Bacteriophage-bacteriophage interactions in the evolution of pathogenic bacteria. Trends Microbiol. 9:137-144. - PubMed
    1. Heinrich, J., M. Velleman, and H. Schuster. 1995. The tripartite immunity system of phages P1 and P7. FEMS Microbiol. Rev. 17:121-126. - PubMed

MeSH terms

LinkOut - more resources