[Meningiomas of the wings of the basilar bone in patients undergone a course of radiation therapy for retinoblastoma in infancy (analysis of 3 cases)]

Abstract

The paper presents 3 cases of radio-induced meningiomas in patients who underwent irradiation for retinoblastoma in infancy. Meningiomas of the middle cranial fossa were diagnosed in women aged 16, 34, and 47 years. Radiation therapy was in the complex treatment of retinoblastoma in all patients in infancy (4 months to 3 years). The latent period between the irradiation and diagnosis of meningioma was 15 to 44 years. The location of detected meningiomas (the wings of the basilar bone on the side of exenteration or enucleation) corresponded to the irradiation fields. Surgical treatment yielded good results. Histological study has indicated that meningiomas were fibroblastic in the former two cases and atypical meningioma was verified in the third case when the tumor infitratively spread. Our observations support the fact that there may be radio-induced meningiomas in the area exposed to irradiation.