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. 1992;180(6):273-8.
doi: 10.1007/BF00191548.

Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen

B Fleischer  1 , C J Bailey
Affiliations

Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen

B Fleischer et al. Med Microbiol Immunol. 1992.

Abstract

The epidermolytic (exfoliative) toxins produced by Staphylococcus aureus cause epidermolysis and skin blistering. In addition, they have been implicated to belong to the group of T lymphocyte stimulating molecules known as "superantigens". Here we show that recombinant epidermolytic toxin A produced in S. aureus is not mitogenic for human and murine T lymphocytes. We discuss the possibility that minute contaminations of highly mitogenic exoproteins may cause the mitogenicity in several proteins that are reported to be superantigens.

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