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. 2004 Oct 19:2:34.
doi: 10.1186/1477-7819-2-34.

Gastric T-cell lymphoma associated with hemophagocytic syndrome

Rika Fukui  1 , Fumitake Hata, Takahiro Yasoshima, Ryuuichi Denno, Minoru Okazaki, Kiyoshi Kasai, Masaaki Sato, Toshio Homma, Keisuke Ohno, Yoshiyuki Yanai, Katsuya Sogahata, Hidefumi Nishimori, Koichi Hirata
Affiliations

Gastric T-cell lymphoma associated with hemophagocytic syndrome

Rika Fukui et al. World J Surg Oncol. .

Abstract

Background: Lymphoma-associated hemophagocytic syndrome (LAHS) occurs in mostly extra nodal non-Hodgkin's lymphoma. LAHS arising from gastrointestinal lymphoma has never been reported. Here we report a case of gastric T-cell lymphoma-associated hemophagocytic syndrome.

Case presentation: A 51-year-old woman presented with pain, redness of breasts, fever and hematemesis. Hematological examination revealed anemia. Gastroscopy revealed small bleeding ulcers in the stomach and the computed tomography scan showed liver tumor. She underwent total gastrectomy for gastrointestinal bleeding and the histopathology revealed gastric T-cell lymphoma. She continued to bleed from the anastomosis and died on the 8th postoperative day. Autopsy revealed it to be a LAHS.

Conclusions: If Hemophagocytic syndrome (HPS) occurs in lymphoma of the gastrointestinal tract, bleeding from the primary lesion might be uncontrollable. Early diagnosis and appropriate treatment are needed for long-term survival.

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Figures

Figure 1
Figure 1
Photomicrograph showing medium-large sized atypical lymphoid cells with pleomorphic features in the stomach suggesting a gastric lymphoma (Hematoxylin and Eosin, ×170).
Figure 2
Figure 2
Photomicrograph of the lymph node at autopsy illustrating histiocytes that show hemophagocytosis of normoblast in a lymph node (Hematoxylin and Eosin, ×200).
See this image and copyright information in PMC

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