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Review
. 2004 Nov;32(Pt 5):826-7.
doi: 10.1042/BST0320826.

Physical and functional interaction between integrins and hERG potassium channels

Affiliations
Review

Physical and functional interaction between integrins and hERG potassium channels

A Arcangeli et al. Biochem Soc Trans. 2004 Nov.

Abstract

Integrins are adhesion receptors capable of transmitting intracellular signals that regulate many different cellular functions. Among integrin-mediated signals, the activation of ion channels can be included. We demonstrated that a long-lasting activation of hERG (human ether-a-go-go-related gene) potassium channels occurs in both human neuroblastoma and leukaemia cells after the activation of the beta1 integrin subunit. This activation is apparently a determining factor inducing neurite extension and osteoclastic differentiation in both the cell types. More recently, we provided evidences that beta1 integrins and hERG channels co-precipitate in both the cell types. Preliminary results suggest that a macromolecular signalling complex indeed occurs between integrins and the hERG1 protein and that hERG channel activity can modulate integrin downstream signalling.

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