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. 2004 Nov 1;39(9):1387-90.
doi: 10.1086/424880. Epub 2004 Oct 11.

Positive predictive value of Gen-Probe APTIMA Combo 2 testing for Neisseria gonorrhoeae in a population of women with low prevalence of N. gonorrhoeae infection

Matthew R Golden  1 , James P Hughes, Linda E Cles, Karen Crouse, Katherine Gudgel, Jinxin Hu, Paul D Swenson, Walter E Stamm, H Hunter Handsfield
Affiliations

Positive predictive value of Gen-Probe APTIMA Combo 2 testing for Neisseria gonorrhoeae in a population of women with low prevalence of N. gonorrhoeae infection

Matthew R Golden et al. Clin Infect Dis. .

Abstract

We collected specimens from women who tested positive for Neisseria gonorrhoeae using the Gen-Probe APTIMA Combo 2 (AC2), and we performed confirmatory tests using a nucleic acid amplification test (NAAT) that targets alternate gonococcal nucleic acid sequences. Among 59,664 specimens, 280 (0.47%) had positive results using AC2; 265 of these specimens were tested using the confirmatory NAAT, of which 258 yielded positive results (positive predictive value, 97.4%; 95% confidence interval, 95.1%-98.8%). Routine confirmatory testing of specimens with positive AC2 gonorrhea test results is not indicated.

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