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Case Reports
. 2004 Nov;77(3):299-302.
doi: 10.1002/ajh.20189.

Rapid irreversible encephalopathy associated with anti-D immune globulin treatment for idiopathic thrombocytopenic purpura

Kenneth Christopher  1 , Clare Horkan, Ilie T Barb, Christian Arbelaez, Travis A Hodgdon, Paul C Yodice
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Free article
Case Reports

Rapid irreversible encephalopathy associated with anti-D immune globulin treatment for idiopathic thrombocytopenic purpura

Kenneth Christopher et al. Am J Hematol. 2004 Nov.
Free article

Abstract

Intravenous Rho (D) immune globulin (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura (ITP). Common side effects of IV RhIG include mild hemolysis, febrile reaction, and headache. Significant hemolysis with renal impairment following IV RhIG has been reported. We report a case of irreversible encephalopathy 48 hr following an infusion of IV RhIG for treatment of ITP.

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