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Review
. 2004 Oct 20;24(42):9250-60.
doi: 10.1523/JNEUROSCI.3649-04.2004.

Mechanisms and roles of axon-Schwann cell interactions

Gabriel Corfas  1 , Miguel Omar Velardez, Chien-Ping Ko, Nancy Ratner, Elior Peles
Affiliations
Review

Mechanisms and roles of axon-Schwann cell interactions

Gabriel Corfas et al. J Neurosci. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Myelinated, unmyelinated, and perisynaptic Schwann cells as seen with the electron microscope. A, Cross section of a myelinated axon of an adult mouse sciatic nerve. The myelin sheath (MS) surrounding the axon (Ax) and the Schwann cell nucleus (S) are clearly visible. B, Cross section of a bundle of unmyelinated axons of an adult mouse sciatic nerve. The Schwann cell forms the Remak bundle, a bouquet-like bundle of thin axons, each separated from its neighbor by thin cytoplasmic extensions of the Schwann cell. C, Cross section of a frog neuromuscular junction reveals three juxtaposed cellular elements: the perisynaptic Schwann cell, nerve terminal (N), and muscle fiber (M). The perisynaptic Schwann cell body (S indicates nucleus) and its processes cap the nerve terminal, but the processes do not wrap around the nerve terminal region facing acetylcholine receptors on muscle.
Figure 2.
Figure 2.
NRG1-erbB signaling and Schwann cell development. During development, neural crest cells give rise to Schwann cell precursors, which then develop into the three adult phenotypes: PSCs, NMSCs, or MSCs. Whereas, during their differentiation into MSCs and NMSCs, the precursors proceed through a stage called immature Schwann cell, the direct precursor of PSCs remains unknown. NRG1-erbB signaling regulates important aspects of Schwann cell biology at each step of their development (see boxed text).
Figure 4.
Figure 4.
Perisynaptic Schwann cells at the neuromuscular junction. Frog skeletal muscle triple labeled with anti-neurofilament for axons (first panel, arrow) and synapsin I antibodies for nerve terminals (first panel, arrowhead), a monoclonal antibody, 2A12, for perisynaptic Schwann cells (second panel, the cell bodies are marked with *), and α-bungarotoxin for postsynaptic acetylcholine receptors (third panel). The merged image is shown in the fourth panel.
Figure 3.
Figure 3.
Molecular structure of the node of Ranvier. Longitudinal section through the nodal region of a peripheral myelinated axon showing the organization and composition of axonal and glial domains. The axon is covered by an MSC, which in turn is surrounded by a basal lamina. In the paranodal region, the myelin sheath forms a series of paranodal loops (PNL) that invaginate and appose the axon creating a septate-like structure. At the node, the outermost cytoplasmic extension of MSC contains numerous microvilli that contact the axolemma. Specific sets of proteins are enriched in each domain of both axon (red text) and Schwann cells (blue text).
Figure 5.
Figure 5.
Schwann cell tumors. In neurofibromas, Schwann cells fibroblasts and perineurial cells are with in collagen-rich tumor matrix; axons and mast cells are common. Neurofibromas are not encapsulated, although the plexiform neurofibroma develops inside the perineurium (not shown). Schwannomas are encapsulated by a collagenous sheath and are made up almost entirely of S100β-positive Schwann cells, with little or no fibroblast involvement; axons are present only at the boundary of the tumor with the associated nerve trunk.
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