doi: 10.1021/np049828f.
Cyanopeptolin 963A, a chymotrypsin inhibitor of Microcystis PCC 7806
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- PMID: 15497957
- DOI: 10.1021/np049828f
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Cyanopeptolin 963A, a chymotrypsin inhibitor of Microcystis PCC 7806
J Nat Prod.
2004 Oct.
Abstract
A new depsipeptide, cyanopeptolin 963 A (1), was isolated from an axenic strain of the toxic freshwater cyanobacterium Microcystis PCC 7806. The structure of this compound was elucidated by chemical and spectroscopic analyses, including high-resolution ESI-FTICR-MS, 2-D NMR, and GC-MS of the hydrolysate. The major structural difference compared to previously characterized cyanopeptolins of this strain is the replacement of the basic amino acid in position 3 by L-tyrosine. Compound 1 displayed inhibitory activity against chymotrypsin with an IC50 value of 0.9 microM.
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