Comparative Study
doi: 10.1023/b:bebm.0000020207.67705.59.
Effects of flavonoids on the resistance of microsomes to lipid peroxidation in vitro and ex vivo
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- PMID: 15500075
- DOI: 10.1023/b:bebm.0000020207.67705.59
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Comparative Study
Effects of flavonoids on the resistance of microsomes to lipid peroxidation in vitro and ex vivo
Bull Exp Biol Med.
2003 Dec.
Abstract
Incubation of rat liver microsomes with preparations of grape flavonoids, dihydroquercetin, and silibinin increased their resistance to lipid peroxidation induced by NADPH-Fe2+. This was manifested in less pronounced accumulation of lipid peroxidation products and changes in activity of microsomal enzymes induced by lipid peroxidation. In vitro antioxidant activity of grape flavonoids markedly surpassed that of dihydroquercetin and silibinin. Addition of flavonoids into fodder led to moderate, statistically significant, and similar increase in the resistance of rat liver microsomes to ex vivo induced lipid peroxidation.
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