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Editorial
. 2004 Oct 25;2(1):36.
doi: 10.1186/1479-5876-2-36.

Granzyme B; the chalk-mark of a cytotoxic lymphocyte

Nigel J Waterhouse  1 , Karin A Sedelies, Chris Jp Clarke
Affiliations
Editorial

Granzyme B; the chalk-mark of a cytotoxic lymphocyte

Nigel J Waterhouse et al. J Transl Med. .

Abstract

During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing. In this way, the released granzyme B can be used to mark the spot where a target cell was murdered. We discuss the benefits and potential limitations of using this assay to measure CL mediated killing of target cells.

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References

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