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. 2004 Dec 6;14(23):5925-9.
doi: 10.1016/j.bmcl.2004.09.034.

Identification of peptidomimetic HTLV-I protease inhibitors containing hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic

Hikoichiro Maegawa  1 , Tooru Kimura, Yasuhiro Arii, Yasuko Matsui, Soko Kasai, Yoshio Hayashi, Yoshiaki Kiso
Affiliations

Identification of peptidomimetic HTLV-I protease inhibitors containing hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic

Hikoichiro Maegawa et al. Bioorg Med Chem Lett. .

Abstract

Towards the development of chemotherapy for the infection by human T-cell leukemia virus type I (HTLV-I), we have established evaluation systems for HTLV-I protease (PR) inhibitors using both recombinant and chemically synthesized HTLV-I PRs. Newly synthesized substrate-based inhibitors containing hydroxymethylcarbonyl (HMC) isostere showed potent anti-HTLV-I PR activity.

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