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Review
. 2004 Nov 15;301(1):60-7.
doi: 10.1016/j.yexcr.2004.08.016.

Aurora kinases in spindle assembly and chromosome segregation

Daniel Ducat  1 , Yixian Zheng
Affiliations
Review

Aurora kinases in spindle assembly and chromosome segregation

Daniel Ducat et al. Exp Cell Res. .

Abstract

The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation.

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