Review
doi: 10.1016/j.yexcr.2004.08.016.
Aurora kinases in spindle assembly and chromosome segregation
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- PMID: 15501446
- DOI: 10.1016/j.yexcr.2004.08.016
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Review
Aurora kinases in spindle assembly and chromosome segregation
Exp Cell Res.
.
Abstract
The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation.
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