[Main determinants of liver microcirculation during systemic inflammation]

Abstract

More than 50% of all patients on intensive care units acquire a systemic inflammation such as systemic inflammatory response syndrome (SIRS) or sepsis. The development of hepatic microcirculatory failure with consecutive organ damage might occur during the course of the systemic inflammation. The liver microcirculation is regulated by a complex network of cellular components and specific mediators. The perfusion in liver sinusoids is regulated by the tonus of the contractile Ito cells. Nitric oxide (NO) and carbon monoxide (CO) influence each other and cause the Ito cells to dilate while endothelin results in a contraction of the Ito cells. On-going studies are investigating the role of angiotensin II, catecholamines and prostaglandins for the regulation of the hepatic microcirculatory system during systemic inflammation. Some investigations aim to determine the impact of sedatives and analgesics on the hepatic microcirculation in sepsis and SIRS. Therefore, a decisive recommendation about the choice and dosage of sedatives and analgesics for these patients is not possible. Nevertheless, ketamine, midazolam and fentanyl with their potential anti-inflammatory properties seem to be suitable for patients with systemic inflammation.