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Review
. 2004:10:123-49.
doi: 10.1016/S1387-2656(04)10005-7.

p75 neurotrophin receptor signaling in the nervous system

Affiliations
Review

p75 neurotrophin receptor signaling in the nervous system

Yuiko Hasegawa et al. Biotechnol Annu Rev. 2004.

Abstract

The neurotrophin receptor p75(NTR) has long been known as a receptor for neurotrophins that promote survival and differentiation. Consistent with the role of neurotrophins, p75(NTR) is expressed during the developmental stages of the nervous system. However, p75(NTR) is re-expressed in various pathological conditions in the adult. We now know that p75(NTR) has the ability to elicit bi-directional signals, that result in the inhibition as well as the promotion of the neurite outgrowth. p75(NTR) is a key receptor for myelin-derived inhibitory cues that contribute to the lack of regeneration of the central nervous system.

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