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Comparative Study
. 2004 Nov;48(11):4430-4.
doi: 10.1128/AAC.48.11.4430-4434.2004.

Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species

Kim L Credito  1 , Peter C Appelbaum
Affiliations
Comparative Study

Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species

Kim L Credito et al. Antimicrob Agents Chemother. 2004 Nov.

Abstract

Agar dilution MIC was used to compare activities of OPT-80, linezolid, vancomycin, teicoplanin, quinupristin/dalfopristin, amoxicillin/clavulanate, imipenem, clindamycin, and metronidazole against 350 gram-positive and -negative anaerobes. OPT-80 was active against gram-positive strains only, especially Clostridium spp. (85 strains tested, including 21 strains of C. difficile), with MICs ranging between </=0.016 and 0.25 microg/ml.

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Figures

FIG. 1.
FIG. 1.
Structure of OPT-80.
See this image and copyright information in PMC

References

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