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. 2004 Nov;48(11):4453-6.
doi: 10.1128/AAC.48.11.4453-4456.2004.

In vitro pharmacodynamic characteristics of amphotericin B, caspofungin, fluconazole, and voriconazole against bloodstream isolates of infrequent Candida species from patients with hematologic malignancies

Giovanni Di Bonaventura  1 , Ilaria Spedicato, Carla Picciani, Domenico D'Antonio, Raffaele Piccolomini
Affiliations

In vitro pharmacodynamic characteristics of amphotericin B, caspofungin, fluconazole, and voriconazole against bloodstream isolates of infrequent Candida species from patients with hematologic malignancies

Giovanni Di Bonaventura et al. Antimicrob Agents Chemother. 2004 Nov.

Abstract

Time-kill and postantifungal effect (PAFE) of amphotericin B, caspofungin, fluconazole, and voriconazole were determined against clinical isolates of Candida guilliermondii, Candida kefyr, and Candida lusitaniae. Azoles displayed fungistatic activity and no measurable PAFE, regardless of the concentration tested. Amphotericin B and caspofungin demonstrated concentration-dependent fungicidal activity, although amphotericin B only produced a significant dose-dependent PAFE against all isolates tested.

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Figures

FIG. 1.
FIG. 1.
Representative time-kill plots for the following: AMB against C. guilliermondii 337 (A) and C. lusitaniae 447 (B); caspofungin against C. kefyr 270 (C); and VRC against C. lusitaniae 325 (D). Antifungals were tested at the following concentrations: 0.125 times the MIC (▴), 0.25 times the MIC (▾), the MIC (⧫), 4 times the MIC (•), and 8 times the MIC (□). ▪, control.
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