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. 2004 Oct 29;119(3):314-6.
doi: 10.1016/j.cell.2004.10.015.

Chronic myeloid leukemia: proving ground for cancer stem cells

George Q Daley  1
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Chronic myeloid leukemia: proving ground for cancer stem cells

George Q Daley. Cell. .
Free article

Abstract

A central question in cancer biology is whether malignancy arises in self-renewing tissue stem cells that suffer oncogene activation or in differentiated cells that acquire properties of unremitting self-renewal? In two papers, Weissman and colleagues document both mechanisms: chronic leukemia arising by mutation affecting the hematopoietic stem cell (HSC) and acute leukemia evolving from committed granulocyte-macrophage progenitors that have acquired the self-renewal machinery of HSCs.

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