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Case Reports
. 2004 Aug 28;33(14 Pt 1):930-3.
doi: 10.1016/s0755-4982(04)98797-0.

[Maternal pancytopenia during antenatal treatment of congenital toxoplasmosis]

[Article in French]
Ndaye Mubiayi  1 , Nadège Coutty, Laurence Detourmignies, Françoise Le Goueff, Jean Decocq, Guy Delahousse
Affiliations
Case Reports

[Maternal pancytopenia during antenatal treatment of congenital toxoplasmosis]

[Article in French]
Ndaye Mubiayi et al. Presse Med. .

Abstract

Introduction: The treatment of reference of congenital toxoplasmosis combines two folate synthesis inhibitors, pyrimethamine and an antibacterial sulfamide (sulfadiazine or sulfadoxine). Despite the efficacy of this combination, the possibility of eventually severe side effects must also be taken into account.

Observation: A pancytopenia occurred at 37 weeks of amenorrhea during antenatal treatment for congenital toxoplasmosis in a tripara. The outcome was positive following administration of strong doses of parenteral folinic acid combined with platelet transfusion and broad-spectrum antibiotics.

Discussion: Each of the molecules (pyrimethamine and antibacterial sulfamide) used for the treatment of congenital toxoplasmosis can lead to acute haematological problems. The occurrence of maternal pancytopenia however remains exceptional. It is principally related to pyrimethamine and is usually observed in the presence of factors enhancing folate deficiency.

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Comment in

  • [Prenatal treatment of congenital toxoplasmosis].
    Chemla C, Villena I, Trenque T, Pinon JM; Groupe Toxoplasmose de Reims. Chemla C, et al. Presse Med. 2005 Dec 17;34(22 Pt 1):1719. doi: 10.1016/s0755-4982(05)84259-9. Presse Med. 2005. PMID: 16374395 French. No abstract available.