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Clinical Trial
. 2004 Nov;161(11):2115-7.
doi: 10.1176/appi.ajp.161.11.2115.

A pilot study of D-cycloserine in subjects with autistic disorder

David J Posey  1 , Deborah L Kem, Naomi B Swiezy, Thayne L Sweeten, Ryan E Wiegand, Christopher J McDougle
Affiliations
Clinical Trial

A pilot study of D-cycloserine in subjects with autistic disorder

David J Posey et al. Am J Psychiatry. 2004 Nov.

Abstract

Objective: The authors assessed the effects of D-cycloserine on the core symptom of social impairment in subjects with autism.

Method: Following a 2-week, single-blind placebo lead-in phase, drug-free subjects with autistic disorder were administered three different doses of D-cycloserine during each of three 2-week periods. Measures used for subject ratings included the Clinical Global Impression (CGI) scale and Aberrant Behavior Checklist.

Results: Significant improvement was found on the CGI and social withdrawal subscale of the Aberrant Behavior Checklist. d-Cycloserine was well tolerated at most of the doses used in this study.

Conclusions: In this pilot study, D-cycloserine treatment resulted in significant improvement in social withdrawal. Further controlled studies of D-cycloserine in autism appear warranted.

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