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Comparative Study
. 2004 Dec;75(6):988-97.
doi: 10.1086/426061. Epub 2004 Oct 22.

Chronic and recurrent otitis media: a genome scan for susceptibility loci

Kathleen A Daly  1 , W Mark Brown, Fernando Segade, Donald W Bowden, Bronya J Keats, Bruce R Lindgren, Samuel C Levine, Stephen S Rich
Affiliations
Comparative Study

Chronic and recurrent otitis media: a genome scan for susceptibility loci

Kathleen A Daly et al. Am J Hum Genet. 2004 Dec.

Abstract

Otitis media (OM) is the most common childhood disease. Almost all children experience at least one episode, but morbidity is greatest in children who experience chronic/recurrent OM (COME/ROM). There is mounting evidence that COME/ROM clusters in families and exhibits substantial heritability. Subjects who had tympanostomy tube surgery for COME/ROM (probands) and their families were recruited for the present study, and an ear examination was performed, without knowledge of the subject's history, to determine presence of OM sequelae. In addition, tympanometric testing was performed at three frequencies (226, 630 or 710, and 1,400 Hz) to detect abnormal middle-ear mechanics, and hearing was screened at 20 dB for the speech frequencies. Of these families, 121 had at least two individuals who had received the diagnosis of COME/ROM (364 affected and genotyped individuals), of whom 238 affected and informative relative pairs were used for analyses. Single-point nonparametric linkage analysis provided evidence of linkage of COME/ROM to chromosome 10q at marker D10S212 (LOD 3.78; P=3.0 x 10(-5)) and to chromosome 19q at marker D19S254 (LOD 2.61; P=5.3 x 10(-4)). Analyses conditional on support for linkage at chromosomes 10q and 19q resulted in a significant increase in LOD score support on chromosome 3p (between markers D3S4545 and D3S1259). These results suggest that risk of COME/ROM is determined by interactions between genes that reside in several candidate regions of the genome and are probably modulated by other environmental risk factors.

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Figures

Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure A1
Figure A1
Genome scan of COME/ROM for each chromosome, by use of multipoint (solid line) and single-point (stars) NPL models.
Figure 1
Figure 1
Genome scan for COME/ROM
Figure 2
Figure 2
Linkage analysis of COME/ROM on chromosome 19, with NPL scores for both multipoint (solid line) and single-point (individual points) approaches.
Figure 3
Figure 3
Linkage analysis of COME/ROM on chromosome 10, with NPL scores for both multipoint (solid line) and single-point (individual points) approaches.
See this image and copyright information in PMC

References

Electronic-Database Information

    1. University of California–Santa Cruz Genome Bioinformatics, http://genome.ucsc.edu/

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