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Review
. 2004 Nov;4(11):850-60.
doi: 10.1038/nrc1476.

Association studies for finding cancer-susceptibility genetic variants

Paul D P Pharoah  1 , Alison M Dunning, Bruce A J Ponder, Douglas F Easton
Affiliations
Review

Association studies for finding cancer-susceptibility genetic variants

Paul D P Pharoah et al. Nat Rev Cancer. 2004 Nov.

Abstract

Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of cancer, and it is likely that many genes with modest effects are yet to be found. Genetic-association studies have been widely used in the search for such genes, but success has been limited so far. Increased knowledge of the function of genes and the architecture of human genetic variation combined with new genotyping technologies herald a new era of gene mapping by association.

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