Review
doi: 10.1038/nri1488.
Forkhead-box transcription factors and their role in the immune system
Affiliations
- PMID: 15516968
- DOI: 10.1038/nri1488
Item in Clipboard
Review
Forkhead-box transcription factors and their role in the immune system
Nat Rev Immunol.
2004 Nov.
Abstract
It is more than a decade since the discovery of the first forkhead-box (FOX) transcription factor in the fruit fly Drosophila melanogaster. In the intervening time, there has been an explosion in the identification and characterization of members of this family of proteins. Importantly, in the past few years, it has become clear that members of the FOX family have crucial roles in various aspects of immune regulation, from lymphocyte survival to thymic development. This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.
Similar articles
-
Human FOX gene family (Review).Int J Oncol. 2004 Nov;25(5):1495-500. Int J Oncol. 2004. PMID: 15492844 Review.
-
Foxo in the immune system.Oncogene. 2008 Apr 7;27(16):2337-44. doi: 10.1038/onc.2008.26. Oncogene. 2008. PMID: 18391975 Review.
-
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.Nat Immunol. 2005 Apr;6(4):331-7. doi: 10.1038/ni1179. Nat Immunol. 2005. PMID: 15785758 Review.
-
Roles of interferon-regulatory factors in T-helper-cell differentiation.Nat Rev Immunol. 2005 Feb;5(2):125-35. doi: 10.1038/nri1552. Nat Rev Immunol. 2005. PMID: 15688040 Review.
-
Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis.J Clin Periodontol. 2009 May;36(5):396-403. doi: 10.1111/j.1600-051X.2009.01390.x. J Clin Periodontol. 2009. PMID: 19419438
Cited by
-
All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells.Front Immunol. 2012 Oct 9;3:312. doi: 10.3389/fimmu.2012.00312. eCollection 2012. Front Immunol. 2012. PMID: 23087689 Free PMC article.
-
FoxO induces pupal diapause by decreasing TGFβ signaling.Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2210404119. doi: 10.1073/pnas.2210404119. Epub 2022 Nov 29. Proc Natl Acad Sci U S A. 2022. PMID: 36442095 Free PMC article.
-
The dual role of FOXF2 in regulation of DNA replication and the epithelial-mesenchymal transition in breast cancer progression.Cell Signal. 2016 Oct;28(10):1502-19. doi: 10.1016/j.cellsig.2016.06.021. Epub 2016 Jul 1. Cell Signal. 2016. PMID: 27377963 Free PMC article.
-
The coordination of T-cell function by serine/threonine kinases.Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a002261. doi: 10.1101/cshperspect.a002261. Cold Spring Harb Perspect Biol. 2011. PMID: 21421912 Free PMC article.
-
Foxj2 overexpression is associated with poor prognosis, progression, and metastasis in nasopharyngeal carcinoma.Onco Targets Ther. 2017 Jul 24;10:3733-3741. doi: 10.2147/OTT.S134915. eCollection 2017. Onco Targets Ther. 2017. PMID: 28769576 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Miscellaneous
