Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Nov;6(11):1062-7.
doi: 10.1038/ncb1104-1062.

A-type lamins: guardians of the soma?

Chris J Hutchison  1 , Howard J Worman
Affiliations
Review

A-type lamins: guardians of the soma?

Chris J Hutchison et al. Nat Cell Biol. 2004 Nov.

Abstract

The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies - inherited diseases that are linked to premature ageing. Recent evidence has demonstrated that lamins A and C have essential functions in protecting cells from physical damage, as well as in maintaining the function of transcription factors required for the differentiation of adult stem cells. Thus, the degenerative nature of laminopathies is explained because these lamins are essential for maintenance of somatic tissues in adulthood.

PubMed Disclaimer

Publication types

LinkOut - more resources