[New insights on the effects of hormone replacement therapy on the breast tissue and the orgnaism]

Abstract

Within the last fifteen to twenty years extensive discussions were held about advantages and disadvantages of postmenopausal hormone replacement therapy. Basing on recent data from prospectively randomized studies the long-term application of a combined estrogen-gestagen therapy for general prophylaxis cannot be recommended. Ongoing studies are expected to provide sufficient data to determine regimens for the prevention of osteoporosis, development of cancer, and cardiovascular diseases.