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Clinical Trial
. 1992 Feb;12(1):19-26.
doi: 10.1097/00001573-199202000-00004.

Treatment of comorbid generalized anxiety in a recently detoxified alcoholic population with a selective serotonergic drug (buspirone)

G D Tollefson  1 , J Montague-Clouse, S L Tollefson
Affiliations
Clinical Trial

Treatment of comorbid generalized anxiety in a recently detoxified alcoholic population with a selective serotonergic drug (buspirone)

G D Tollefson et al. J Clin Psychopharmacol. 1992 Feb.

Abstract

Recent literature has addressed a common dyad: alcoholism and anxiety. Both disorders have been interdigitated with the brain amine serotonin. We investigated 51 dually diagnosed patients (generalized anxiety/alcohol abuse:dependence) in a randomized, double-blind, placebo-controlled trial of the serotonin partial agonist buspirone. Buspirone was superior to placebo as an anxiolytic, was well tolerated, and was associated with both a reduction in the number of days desiring alcohol and an overall clinical global improvement.

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