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. 2004 Nov;52(11):1269-72.
doi: 10.1248/cpb.52.1269.

Enzyme inhibiting lignans from Vitex negundo

Azhar-Ul-Haq  1 , Abdul Malik, Itrat Anis, Sher Bahadar Khan, Ejaz Ahmed, Zaheer Ahmed, Sarfraz Ahmad Nawaz, Muhammad Iqbal Choudhary
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Free article

Enzyme inhibiting lignans from Vitex negundo

Azhar-Ul-Haq et al. Chem Pharm Bull (Tokyo). 2004 Nov.
Free article

Abstract

Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.

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