Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Nov;4(11):672-83.
doi: 10.1016/S1473-3099(04)01173-9.

Epidemiological and genetic analysis of severe acute respiratory syndrome

Affiliations
Review

Epidemiological and genetic analysis of severe acute respiratory syndrome

Christl A Donnelly et al. Lancet Infect Dis. 2004 Nov.

Abstract

The severe acute respiratory syndrome (SARS) epidemics in 2002-2003 showed how quickly a novel infectious disease can spread both within communities and internationally. We have reviewed the epidemiological and genetic analyses that have been published both during and since these epidemics, and show how quickly data were collected and analyses undertaken. Key factors that determine the speed and scale of transmission of an infectious disease were estimated using statistical and mathematical modelling approaches, and phylogenetic analyses provided insights into the origin and evolution of the SARS-associated coronavirus. The SARS literature continues to grow, and it is hoped that international collaboration in the analysis of epidemiological and contact-network databases will provide further insights into the spread of this newly emergent infectious disease.

PubMed Disclaimer

Figures

Figure
Figure
Computer generated image of SARS coronavirus.

References

    1. WHO Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003 (based on data as of the 31 December 2003) http://www.who.int/csr/sars/country/table2004_04_21/en/ (accessed Sept 22, 2004).
    1. Centers for Disease Control and Prevention Revised US surveillance case definition for severe acute respiratory syndrome (SARS) and update on SARS cases: United States and worldwide, December 2003. MMWR Morb Mortal Wkly Rep. 2003;52:1202–1206. - PubMed
    1. Centers for Disease Control and Prevention . Revised CSTE SARS surveillance case definition [appendix 1 of supplement B of the public health guidance for community-level preparedness response to severe acute respiratory syndrome (SARS)] Centers for Disease Control and Prevention; Atlanta, GA: 2004.
    1. Lim PL, Kurup A, Gopalakrishna G. Laboratory-acquired severe acute respiratory syndrome. N Engl J Med. 2004;350:1740–1745. - PubMed
    1. Orellana C. Laboratory-acquired SARS raises worries on biosafety. Lancet Infect Dis. 2004;4:64. 64. - PMC - PubMed

MeSH terms

LinkOut - more resources