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. 2004 Nov 25;811(2):201-8.
doi: 10.1016/j.jchromb.2004.09.002.

Investigation of the silylation of ephedrines using N-methyl-N-trimethylsilyl-trifluoroacetamide

Guro Forsdahl  1 , Günter Gmeiner
Affiliations

Investigation of the silylation of ephedrines using N-methyl-N-trimethylsilyl-trifluoroacetamide

Guro Forsdahl et al. J Chromatogr B Analyt Technol Biomed Life Sci. .

Abstract

This paper describes a gas chromatography (GC)--mass spectrometry (MS) method for the simultaneous quantification of ephedrine, pseudoephedrine, cathine, norephedrine and methylephedrine in urine. The sample preparation step includes solid phase extraction and derivatisation with N-methyl-N-trimethylsilyl-trifluoroacetamide (MSTFA). An evaluation of various silylation conditions compatible with screening methods in doping control analysis is presented. The method was found to be well suited for quantification of ephedrines in doping control.

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