Review
doi: 10.1038/nsmb852.
Assembling the mitochondrial outer membrane
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- PMID: 15523480
- DOI: 10.1038/nsmb852
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Review
Assembling the mitochondrial outer membrane
Nat Struct Mol Biol.
2004 Nov.
Abstract
The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology.
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