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Review
. 2004 Nov;11(11):1044-8.
doi: 10.1038/nsmb852.

Assembling the mitochondrial outer membrane

Nikolaus Pfanner  1 , Nils Wiedemann, Chris Meisinger, Trevor Lithgow
Affiliations
Review

Assembling the mitochondrial outer membrane

Nikolaus Pfanner et al. Nat Struct Mol Biol. 2004 Nov.

Abstract

The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology.

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