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. 2004 Nov 11;6(23):4327-30.
doi: 10.1021/ol0481535.

Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) hara

Sheng-Hong Li  1 , Jia Wang, Xue-Mei Niu, Yun-Heng Shen, Hong-Jie Zhang, Han-Dong Sun, Ma-Lin Li, Qin-E Tian, Yang Lu, Peng Cao, Qi-Tai Zheng
Affiliations

Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) hara

Sheng-Hong Li et al. Org Lett. .

Abstract

Maoecrystal V (1), a novel C(19) diterpenoid possessing a unique 6,7-seco-6-nor-15(8-->9)-abeo-5,8-epoxy-ent-kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC(50) = 0.02 microg/mL (cis-platin: IC(50) = 0.99 microg/mL).

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