Review
Trend in randomized controlled trials
Affiliations
- PMID: 15526517
Item in Clipboard
Review
Trend in randomized controlled trials
Rom J Intern Med.
2003.
Abstract
Virtually any study may achieve statistical significance if we increase the sample size indefinitely. We cannot discuss about trend without interpreting confidence intervals (CI). The sample size being computed function of the magnitude of the clinical effect is considered worth detecting, when the result is not statistically significant, it is neither clinically significant. Increasing the sample, the "trend" can disappear or even change its direction.
Similar articles
-
The value of RCT evidence depends on the quality of statistical analysis.Behav Res Ther. 2008 Feb;46(2):270-81. doi: 10.1016/j.brat.2007.12.001. Epub 2007 Dec 5. Behav Res Ther. 2008. PMID: 18191102
-
Size of treatment effects and their importance to clinical research and practice.Biol Psychiatry. 2006 Jun 1;59(11):990-6. doi: 10.1016/j.biopsych.2005.09.014. Epub 2005 Dec 20. Biol Psychiatry. 2006. PMID: 16368078 Review.
-
Sample size calculations in randomized trials: common pitfalls.Can J Anaesth. 2007 Feb;54(2):103-6. doi: 10.1007/BF03022005. Can J Anaesth. 2007. PMID: 17272248 English, French. No abstract available.
-
The journal impact factor as a predictor of trial quality and outcomes: cohort study of hepatobiliary randomized clinical trials.Am J Gastroenterol. 2005 Nov;100(11):2431-5. doi: 10.1111/j.1572-0241.2005.00327.x. Am J Gastroenterol. 2005. PMID: 16279896
-
Efficient ways exist to obtain the optimal sample size in clinical trials in rare diseases.J Clin Epidemiol. 2008 Apr;61(4):324-30. doi: 10.1016/j.jclinepi.2007.07.008. Epub 2008 Feb 21. J Clin Epidemiol. 2008. PMID: 18313556 Review.