Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003;41(3):329-32.

Trend in randomized controlled trials

C Băicuş  1
Affiliations
  • PMID: 15526517
Review

Trend in randomized controlled trials

C Băicuş. Rom J Intern Med. 2003.

Abstract

Virtually any study may achieve statistical significance if we increase the sample size indefinitely. We cannot discuss about trend without interpreting confidence intervals (CI). The sample size being computed function of the magnitude of the clinical effect is considered worth detecting, when the result is not statistically significant, it is neither clinically significant. Increasing the sample, the "trend" can disappear or even change its direction.

PubMed Disclaimer