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. 2004 Nov;42(11):5362-3.
doi: 10.1128/JCM.42.11.5362-5363.2004.

False-positive Aspergillus galactomannan enzyme-linked immunosorbent assay results in vivo during amoxicillin-clavulanic acid treatment

Daniele Mattei  1 , Davide Rapezzi, Nicola Mordini, Federica Cuda, Cristiana Lo Nigro, Maura Musso, Aldo Arnelli, Sebastiano Cagnassi, Andrea Gallamini
Affiliations

False-positive Aspergillus galactomannan enzyme-linked immunosorbent assay results in vivo during amoxicillin-clavulanic acid treatment

Daniele Mattei et al. J Clin Microbiol. 2004 Nov.

Abstract

Positive Platelia Aspergillus test results were observed in consecutive serum samples from an immunocompromised host during amoxicillin-clavulanic acid treatment, and a correlation between plasmatic amoxicillin concentration and galactomannan optical density index was observed. Amoxicillin-clavulanic acid vials tested positive for galactomannan but were negative for Aspergillus DNA.

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Figures

FIG. 1.
FIG. 1.
Correlation between plasmatic amoxicillin concentration (AMX conc) and GM OD index. AMC treatment was begun on day 47 and was discontinued on day 58.
See this image and copyright information in PMC

References

    1. Adam, O., A. Auperin, F. Wilquin, J. H. Bourhis, B. Gachot, and E. Chachaty. 2004. Treatment with piperacillin-tazobactam and false-positive Aspergillus galactomannan antigen test results for patients with hematological malignancies. Clin. Infect. Dis. 38:917-920. - PubMed
    1. Ansorg, R., R. Van Den Boom, and P. M. Rath. 1997. Detection of Aspergillus galactomannan antigen in foods and antibiotics. Mycoses. 40:353-357. - PubMed
    1. Heinsele, H., H. Hebart, G. Roller, J. Loffler, I. Rothenhofer, C. A. Muller, R. A. Bowden, J. van Burik, D. Engelhard, L. Kanz, and U. Schumacher. 1997. PCR for detection and differentiation of various fungal pathogens in blood samples. J. Clin. Microbiol. 35:1353-1360. - PMC - PubMed
    1. Kappe, R., and A. Schulze-Berge. 1993. New cause for false-positive results with the Pastorex Aspergillus antigen latex agglutination test. J. Clin. Microbiol. 31:2489-2490. - PMC - PubMed
    1. Maertens, J., J. Verhaegen, K. Lagrou, J. Van Eldere, and M. Boogaerts. 2001. Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation. Blood. 97:1604-1610. - PubMed

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