Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Nov;42(11):5364-7.
doi: 10.1128/JCM.42.11.5364-5367.2004.

Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada

Raymond S W Tsang  1 , Allan K H Lau, Michelle L Sill, Scott A Halperin, Paul Van Caeseele, Frances Jamieson, Irene E Martin
Affiliations

Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada

Raymond S W Tsang et al. J Clin Microbiol. 2004 Nov.

Abstract

The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Polymorphisms in the amino acid sequence of the Fim3 protein of B. pertussis. Letters refer to amino acid residues. Dots indicate identity. Boxed regions indicate Fim3 epitopes recognized by human sera (25), suggesting surface location.
FIG. 1.
FIG. 1.
Polymorphisms in the amino acid sequence of the Fim3 protein of B. pertussis. Letters refer to amino acid residues. Dots indicate identity. Boxed regions indicate Fim3 epitopes recognized by human sera (25), suggesting surface location.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abdillahi, H., and J. T. Poolman. 1987. Whole-cell ELISA for typing Neisseria meningitidis with monoclonal antibodies. FEMS Microbiol. Lett. 48:367-371. - PubMed
    1. Ashworth, L. A. E., L. I. Irons, and A. B. Dowsett. 1982. Antigenic relationship between serotype-specific agglutinogen and fimbriae of Bordetella pertussis. Infect. Immun. 37:1278-1281. - PMC - PubMed
    1. Bentsi-Enchill, A., S. A. Halperin, J. Scott, K. MacIsaac, and P. Duclos. 1997. Estimates of the effectiveness of a whole-cell pertussis vaccine from an outbreak in an immunized population. Vaccine 15:301-306. - PubMed
    1. Boursaux-Eude, C., S. Thiberge, G. Carletti, and N. Guiso. 1999. Intranasal murine model of Bordetella pertussis infection: II. Sequence variation and protection induced by a tricomponent acellular vaccine. Vaccine 17:2651-2660. - PubMed
    1. Cassiday, P., G. Sanden, K. Heuvelman, F. Mooi, K. M. Bisgard, and T. Popovic. 2000. Polymorphisms in Bordetella pertussis pertactin and pertussis toxin virulence factors in the United States, 1935-1999. J. Infect. Dis. 182:1402-1408. - PubMed

Publication types

MeSH terms

Associated data

LinkOut - more resources