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. 2004 Nov;42(11):5364-7.
doi: 10.1128/JCM.42.11.5364-5367.2004.

Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada

Raymond S W Tsang  1 , Allan K H Lau, Michelle L Sill, Scott A Halperin, Paul Van Caeseele, Frances Jamieson, Irene E Martin
Affiliations

Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada

Raymond S W Tsang et al. J Clin Microbiol. 2004 Nov.

Abstract

The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.

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Figures

FIG. 1.
FIG. 1.
Polymorphisms in the amino acid sequence of the Fim3 protein of B. pertussis. Letters refer to amino acid residues. Dots indicate identity. Boxed regions indicate Fim3 epitopes recognized by human sera (25), suggesting surface location.
FIG. 1.
FIG. 1.
Polymorphisms in the amino acid sequence of the Fim3 protein of B. pertussis. Letters refer to amino acid residues. Dots indicate identity. Boxed regions indicate Fim3 epitopes recognized by human sera (25), suggesting surface location.
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