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. 2004 Oct;59(10):977-83.
doi: 10.1093/gerona/59.10.b977.

Genetic loci that influence cause of death in a heterogeneous mouse stock

Ruth Lipman  1 , Andrzej Galecki, David T Burke, Richard A Miller
Affiliations

Genetic loci that influence cause of death in a heterogeneous mouse stock

Ruth Lipman et al. J Gerontol A Biol Sci Med Sci. 2004 Oct.

Abstract

A genome scan was conducted to seek evidence for polymorphic genes that influence cause of death in mice produced by a cross between CB6F1 females and C3D2F1 males. Loci on chromosomes 1 and 4 were found to modulate risk of lymphoma. A locus on chromosome 4 influenced risk of mammary adenocarcinoma among multiparous female mice, but had no significant effect in virgin females. A chromosome 4 locus was found to modulate risk of death from either hemangiosarcoma or fibrosarcoma. A suggestive linkage was noted (at p =.09) between a marker on chromosome 11 and hepatocellular carcinoma. Lastly, a locus on chromosome 6 was noted to influence the likelihood that pulmonary adenocarcinoma would be present at death. The collection of normal and neoplastic tissues from 1004 terminal necropsies, together with genetic information, provides a valuable resource for further studies of the genetic influences on late-life diseases in mice.

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Figures

Figure 1.
Figure 1.
Each bar corresponds to the number of mice with the indicated allele (top panels) or combination of alleles (bottom panel), pooled across all three experimental populations. The top portion of each bar corresponds to the number of cases for which lymphoma was the cause of death; the bottom portion represents all other diagnoses. The percentages in the bottom figure show the proportion of lymphoma cases compared to the total number of mice with each of the four possible allele combinations. In the bottom figure, the allele at D1Mit206 is listed followed by the allele at D4Mit84. COD = cause of death
Figure 2.
Figure 2.
Each bar corresponds to the number of multiparous female mice with the indicated allele. The top portion of each bar corresponds to the number of cases for which mammary adenocarcinoma was the cause of death; the bottom portion represents all other diagnoses. COD = cause of death; CA = carcinoma
See this image and copyright information in PMC

References

    1. Chrisp CE, Turke P, Luciano A, Swalwell S, Peterson J, Miller RA. Lifespan and pathology in genetically heterogeneous (four-way cross) mice: a new model for aging research. Vet Pathol. 1996;33:735-743. - PubMed
    1. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd Ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 1989.
    1. Jackson AU, Fornes A, Galecki A, Miller RA, Burke DT. Multiple-trait quantitative trait loci analysis using a large mouse sibship. Genetics. 1999;151:785-795. - PMC - PubMed
    1. Volkman SK, Galecki AT, Burke DT, et al. Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003;18:1497-1505. - PubMed
    1. Galecki AT, Ten Have TR, Molenberghs G. A simple and fast alternative to the EM algorithm for incomplete categorical data and latent class models. Comput Stat Data Anal. 2001;35:265-281.

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