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. 2004 Nov;364(9446):1699-700.
doi: 10.1016/S0140-6736(04)17357-1.

The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

Kathleen M Gillespie  1 , Steven C Bain, Anthony H Barnett, Polly J Bingley, Michael R Christie, Geoffrey V Gill, Edwin A M Gale
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The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

Kathleen M Gillespie et al. Lancet. 2004 Nov.

Abstract

The incidence of childhood type 1 diabetes has risen over the past 50 years. We compared the frequency of HLA class II haplotypes in 194 patients diagnosed more than 50 years ago and 582 age-matched and sex-matched individuals diagnosed between 1985 and 2002. The proportion of high-risk susceptibility genotypes was increased in the earlier cohort (p=0.003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect.

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