Synthesis of phosphonic analogues of carnitine and gamma-amino-beta-hydroxybutyric acid
- PMID: 15530988
- DOI: 10.1016/j.bioorg.2004.05.009
Synthesis of phosphonic analogues of carnitine and gamma-amino-beta-hydroxybutyric acid
Abstract
The involvement of carnitine and gamma-amino-beta-hydroxybutyric acid in the biology of mammalian cells, the physiology of the human body, and some important aspects of medicinal treatment has induced many research groups to develop their pharmacologically potent analogues. Among them are the very important phosphonic analogues: phosphocarnitine and gamma-amino-beta-hydroxypropylphosphonic acid. This mini-review describes the various methodologies used for the synthesis of these compounds.
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