Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004;30(3):309-25.
doi: 10.1385/IR:30:3:309.

Manipulating the type 1 vs type 2 balance in type 1 diabetes

Urs Christen  1 , Matthias G von Herrath
Affiliations
Review

Manipulating the type 1 vs type 2 balance in type 1 diabetes

Urs Christen et al. Immunol Res. 2004.

Abstract

Virus infections cause a strong inflammatory reaction that is dominated by the expression of type 1 cytokines and chemokines. Such an aggressive immune response by the host is necessary to eliminate intracellular pathogens. However, because of this shift in the type 1 vs type 2 balance of the immune response, virus infections are potential candidates for triggering autoimmune diseases, such as type 1 diabetes (T1D), herpes stromal keratitis, or multiple sclerosis (MS). In this review we will focus on the pathogenesis of T1D in a virus-induced transgenic mouse model and discuss possibilities of how an aggressive type 1-dominated immune response can be restrained and autoimmunity be abrogated.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Diabetes Metab Rev. 1995 Jul;11(2):83-107 - PubMed
    1. Transplantation. 2000 Mar 27;69(6):1147-55 - PubMed
    1. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2257-9 - PubMed
    1. J Immunol. 2003 Jul 1;171(1):469-76 - PubMed
    1. J Clin Invest. 1994 Nov;94(5):2125-9 - PubMed

Publication types

LinkOut - more resources