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. 1992 Feb;9(2):178-81.
doi: 10.1023/a:1018920903436.

Potentiation of cytotoxicity of mitoxantrone toward CHO-K1 cells in vitro by dipyridamole

P B Desai  1 , R Sridhar
Affiliations

Potentiation of cytotoxicity of mitoxantrone toward CHO-K1 cells in vitro by dipyridamole

P B Desai et al. Pharm Res. 1992 Feb.

Abstract

Dipyridamole (DP), a clinically used vasodilator and an antiplatelet compound, augmented the activity of the anticancer drug mitoxantrone (MXN) toward chinese hamster ovary (CHO-K1) cells in culture. Clonogenic assays indicated that DP (1.0, 2.5, and 5.0 microM) decreased the survival of cells treated with MXN (5 to 25 nM) in a dose-dependent manner. Further, DP (1 and 5 microM) decreased the MXN concentration required for 50% inhibition of cell growth from 3.2 to 1.8 and from 3.0 to 0.5 nM, respectively, over a period of 3 days. DP (10 microM) increased the accumulation of MXN by 1.8-fold in exponentially growing cells exposed to MXN. The enhanced levels of MXN in CHO-K1 cells in the presence of the chemosensitizer may account for the potentiation of MXN-cytotoxicity by DP.

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References

    1. Cancer Res. 1986 Jun;46(6):3168-72 - PubMed
    1. Cancer Res. 1988 Mar 1;48(5):1208-12 - PubMed
    1. Biochim Biophys Acta. 1977 Jun 2;467(2):238-50 - PubMed
    1. Biochem Biophys Res Commun. 1986 Apr 29;136(2):521-8 - PubMed
    1. Cancer Res. 1988 Oct 1;48(19):5585-90 - PubMed

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