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Review
. 2004;5(11):247.
doi: 10.1186/gb-2004-5-11-247. Epub 2004 Nov 1.

Uncovering the complexities of Kaposi's sarcoma through genome-wide expression analysis

Daniel Di Bartolo  1 , Ethel Cesarman
Affiliations
Review

Uncovering the complexities of Kaposi's sarcoma through genome-wide expression analysis

Daniel Di Bartolo et al. Genome Biol. 2004.

Abstract

Gene-expression profiling of endothelial cells infected with Kaposi's sarcoma-associated herpesvirus has led to a greater understanding of the histogenesis of Kaposi's sarcoma and cellular reprogramming events that occur as a result of viral infection and that may play important roles in viral pathogenesis.

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Figures

Figure 1
Figure 1
Infection of blood vascular endothelial cells and lymphatic endothelial cells with KSHV. The study by Wang et al. [1] found that the infected cells have a transcription profile that lies between those of the two starting cell types but is closer to that of lymphatic endothelium. In most cells the virus establishes a latent infection, whereas a small proportion develop a lytic infection.
See this image and copyright information in PMC

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References

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