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Review
. 2004;5(11):247.
doi: 10.1186/gb-2004-5-11-247. Epub 2004 Nov 1.

Uncovering the complexities of Kaposi's sarcoma through genome-wide expression analysis

Daniel Di Bartolo  1 , Ethel Cesarman
Affiliations
Review

Uncovering the complexities of Kaposi's sarcoma through genome-wide expression analysis

Daniel Di Bartolo et al. Genome Biol. 2004.

Abstract

Gene-expression profiling of endothelial cells infected with Kaposi's sarcoma-associated herpesvirus has led to a greater understanding of the histogenesis of Kaposi's sarcoma and cellular reprogramming events that occur as a result of viral infection and that may play important roles in viral pathogenesis.

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Figures

Figure 1
Figure 1
Infection of blood vascular endothelial cells and lymphatic endothelial cells with KSHV. The study by Wang et al. [1] found that the infected cells have a transcription profile that lies between those of the two starting cell types but is closer to that of lymphatic endothelium. In most cells the virus establishes a latent infection, whereas a small proportion develop a lytic infection.
See this image and copyright information in PMC

References

    1. Wang H-W, Trotter MWB, Lagos D, Bourboulia D, Henderson S, Mäkinen T, Elliman S, Flanagan AM, Alitalo K, Boshoff C. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression profile of Kaposi sarcoma. Nat Genet. 2004;36:687–693. doi: 10.1038/ng1384. - DOI - PubMed
    1. Glaunsinger B, Ganem D. Highly selective escape from KSHV-mediated host mRNA shutoff and its implications for viral pathogenesis. J Exp Med. 2004;200:391–398. doi: 10.1084/jem.20031881. - DOI - PMC - PubMed
    1. Poole LJ, Yu Y, Kim PS, Zheng QZ, Pevsner J, Hayward GS. Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus. J Virol. 2002;76:3395–3420. doi: 10.1128/JVI.76.7.3395-3420.2002. - DOI - PMC - PubMed
    1. Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BG, Griffith DJ, Wait CL, Druker BJ, Heinrich MC, et al. Kaposi's sarcoma-associated herpesvirus-induced up-regulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells. J Virol. 2002;76:8383–8399. doi: 10.1128/JVI.76.16.8383-8399.2002. - DOI - PMC - PubMed
    1. Naranatt PP, Krishman HH, Svojanovsky SR, Bloomer C, Mathur S, Chandran B. Host gene induction and transcriptional reprogramming in Kaposi's sarcoma associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infection. Cancer Res. 2004;64:72–84. - PubMed