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Comparative Study
. 2004 Oct;96(10):678-82; 683-6.
doi: 10.4321/s1130-01082004001000002.

Influence of rofecoxib on experimental colonic carcinogenesis in rats

[Article in English, Spanish]
J F Noguera Aguilar  1 , A Plaza Martínez, I Amengual Antich, J M Morón Canis, C Tortajada Collado, J J Pujol Tugores
Affiliations
Free article
Comparative Study

Influence of rofecoxib on experimental colonic carcinogenesis in rats

[Article in English, Spanish]
J F Noguera Aguilar et al. Rev Esp Enferm Dig. 2004 Oct.
Free article

Abstract

Aim: To investigate the effect of a selective cyclooxigenase-2 (COX-2) inhibitor, rofecoxib, in the prevalence of experimental colon tumors in rats.

Experimental design: Experimental study with 35 male Sprague-Dawley rats, divided into four groups: a) control group without experimental manipulation (n = 5); b) pharmacological carcinogenesis with 1-2 dimethylhydrazine dihydrocloride (n = 10); c) pharmacological carcinogenesis and addition of acetylsalicylic acid (AAS) (n = 10); and d) carcinogenesis and addition of rofecoxib (n = 10). Carcinogenesis was induced with 1-2 dimethylhydrazine at a weekly dose of 25 mg/kg for 18 weeks. Colon tumors were isolated at 20 weeks. Antiinflammatory agents were given at a dose of AAS 30 mg/kg and rofecoxib at 3 mg/kg.

Results: The percentage of colonic tumors was significantly reduced in the rofecoxib group. This result was found for all tumors and for the malignant lesions, adenocarcinomas.

Conclusions: Rofecoxib, a selective COX-2 inhibitor, reduced the percentage of drug-induced neoplastic glandular tissue in rats.

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Comment in

  • Colorectal cancer and Coxibs.
    Taxonera C, Mendoza JL. Taxonera C, et al. Rev Esp Enferm Dig. 2004 Oct;96(10):673-5; 675-7. doi: 10.4321/s1130-01082004001000001. Rev Esp Enferm Dig. 2004. PMID: 15537373 English, Spanish. No abstract available.

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