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. 2004 Nov 11;2(1):10.
doi: 10.1186/1477-9560-2-10.

Thromboembolic events and haematological diseases: a case of stroke as clinical onset of a paroxysmal nocturnal haemoglobinuria

Gianluca Granata  1 , Tiziana Izzo, Pierpaolo Di Micco, Barbara Bonamassa, Giampiero Castaldo, Vito Giuseppe Viggiano, Ugo Picillo, Giuseppe Castaldo, Alferio Niglio
Affiliations

Thromboembolic events and haematological diseases: a case of stroke as clinical onset of a paroxysmal nocturnal haemoglobinuria

Gianluca Granata et al. Thromb J. .

Abstract

Some haematological diseases are associated to an increased risk of thromboembolic events. We report a case of paroxysmal nocturnal haemoglobinuria (PNH) in which a cerebrovascular event represented the first clinical manifestation of disease. PNH is associated to thromboembolic events, generally of venous districts often involving unusual locations such as mesenteric vessels, sagittal veins, inferior vena cava and renal veins.To our knowledge arterial thrombotic episodes are rare and the involvement of arterial cerebral vessels is exceptional. Then, our case points out the importance of investigating about haematological disorders in all patients presenting with a stroke, in which the common predisposing conditions are excluded.

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Figures

Figure 1
Figure 1
Magnetic resonance imaging scan showing multiple ischemic lesions in left cerebral peduncle (1A) and semioval centres (1B).
See this image and copyright information in PMC

References

    1. J. Meletis, E. Terpos. Recent insights into the phatophysiology of the paroxysmal nocturnal haemoglobinuria. Med Sci Monit. 2003;9:RA161–172. - PubMed
    1. Rosse WF, Nishimura J. Clinical manifestations of paroxysmal nocturnal haemoglobinuria: present state and future problems. Int J Hematol. 2003;77:113–20. - PubMed
    1. Leone G, Sica S, Chiusolo P, Teofili L, De Stefano V. Blood cell diseases and thrombosis. Haematologica. 2001;86:1236–44. - PubMed
    1. Graham ML, Rosse WF, Halperin EC, Miller CR, Are RE. Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria. Br J Haematol. 1996;92:707–10. doi: 10.1046/j.1365-2141.1996.365901.x. - DOI - PubMed
    1. von Stuckrad-Barre S, Berkefeld J, Steckel D, Sitzer M. Cerebral arterial thrombosis in paroxysmal nocturnal haemoglobinuria. J Neurol. 2003;250:756–7. doi: 10.1007/s00415-003-1071-7. - DOI - PubMed

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