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Review
. 2004 Nov;11(6):987-95.
doi: 10.1128/CDLI.11.6.987-995.2004.

Antigenic diversity and immune evasion by malaria parasites

Marcelo U Ferreira  1 , Mônica da Silva Nunes, Gerhard Wunderlich
Affiliations
Review

Antigenic diversity and immune evasion by malaria parasites

Marcelo U Ferreira et al. Clin Diagn Lab Immunol. 2004 Nov.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Simplified life cycle of malaria parasites in human hosts. The parasite development within mosquito vectors is not represented.
FIG. 2.
FIG. 2.
Schematic representation of three major malarial surface antigens. Amino acid sequences of CSP repeat motifs are shown for P. falciparum and the two variants of P. vivax. MSP-1 of P. falciparum was divided into 17 blocks according to the levels of interallele sequence divergence (111). MSP-1 of P. vivax was divided into 13 blocks (87). MSP-2 of P. falciparum was divided into five blocks (107); the central repeats differ both between and within dimorphic families.
FIG. 3.
FIG. 3.
(A) Structures of the different variant multigene families of P. falciparum and P. vivax. Var genes have two exons and code for a various number of domains with different adhesive properties, termed Duffy binding-like domains (α, β, γ, δ, etc.) and cysteine-rich interdomain regions (CIDR) (106). Vir genes have three exons. Probable (gray) or confirmed (black) regions coding for transmembrane domains are indicated with helices. ATS, acidic terminal segment. (B) Proposed model of ectopic exchange of telomeres. Chromosome telomeres cluster in bouquet-like structures at perinuclear regions. The similarity among the repetitive telomere elements (TAREs) and the var, stevor, and rif genes (represented by boxes with different patterns) are believed to facilitate the recombination between chromosomes. Modified from reference with permission of the publisher.
See this image and copyright information in PMC

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