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. 2004;22(6):510-7.
doi: 10.1159/000082042. Epub 2004 Nov 10.

Vitamin E-coated dialyzer membranes downregulate expression of monocyte adhesion and co-stimulatory molecules

Michiel G H Betjes  1 , Franciska M E Hoekstra, M Klepper, Saskia M Postma, Leonard M B Vaessen
Affiliations

Vitamin E-coated dialyzer membranes downregulate expression of monocyte adhesion and co-stimulatory molecules

Michiel G H Betjes et al. Blood Purif. 2004.

Abstract

Background: In patients on chronic hemodialysis leukocyte activation has been related to the impaired function of the immune system. In this study we investigated if the vitamin E-coated dialyzer membrane could reduce monocyte activation thereby improving cellular immunity.

Methods: This hypothesis was tested in a prospective crossover trial in which 14 stable hemodialysis patients were switched from the baseline hemophane dialyzer to a vitamin E-coated and thereafter a polysulphone dialyzer membrane or vice versa.

Results: Monocyte MHC class I, CD54 and ICAM-1 expression was significantly downregulated when a vitamin E-coated or polysulphone dialyzer was used. The use of a vitamin E membrane specifically decreased monocyte CD40 and CD86 expression. Lectin induced T cell proliferation increased with the use of the vitamin E-coated membrane as compared to polysulphone and hemophane dialyzers.

Conclusion: Vitamin E-coated dialyzers induced a less-activated phenotype of monocytes and may improve cellular immunity.

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